- Causes Of Restless Legs
- Medication Restless Legs Syndrome
- Drugs That Cause Restless Legs
- Requip Medication For Restless Leg Syndrome
Dopaminergic agents are commonly used and effective treatments for restless legs syndrome (RLS), a disabling sensorimotor disorder. Less known are some of the potentially disabling side effects of these treatments, particularly iatrogenic gambling addiction, as is described here. A 60-year-old woman with restless legs syndrome (RLS) lost about $6000 per month due to an 'uncontrollable urge' to play slot machines. A 70-year-old woman with Parkinson disease (PD) bought.
Pramipexole is used alone or with other medications to treat the symptoms of Parkinson's disease (PD; a disorder of the nervous system that causes difficulties with movement, muscle control, and balance), including shaking of parts of the body, stiffness, slowed movements, and problems with balance. Pramipexole is also used to treat restless legs syndrome (RLS; a condition that causes discomfort in the legs and a strong urge to move the legs, especially at night and when sitting or lying down). Pramipexole is in a class of medications called dopamine agonists. It works by acting in place of dopamine, a natural substance in the brain that is needed to control movement.
Pramipexole comes as a tablet and an extended-release (long-acting) tablet to take by mouth. When pramiprexole is used to treat Parkinson's disease, the regular tablet is usually taken three times a day and the extended-release tablet is usually taken once daily. When pramiprexole is used to treat restless legs syndrome, the regular tablet is usually taken once a day, 2 to 3 hours before bedtime. Pramipexole extended-release tablets are not used to treat restless legs syndrome. Pramipexole may be taken with or without food, but taking pramipexole with food may help to prevent nausea that may be caused by the medication. Follow the directions on your prescription label carefully and ask your doctor or pharmacist to explain any part you do not understand. Take pramipexole exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Swallow the extended-release tablets whole; do not split, chew, or crush them.
Your doctor will start you on a low dose of pramipexole and gradually increase your dose. Your doctor will probably not increase your dose more often than once every 4 to 7 days. It may take several weeks before you reach a dose that works for you.
If you are taking pramipexole to treat restless legs syndrome, you should know that as your treatment continues, your symptoms may worsen, may begin earlier in the evening or afternoon, or may occur in the early morning. Call your doctor if your symptoms worsen or if they begin to occur at different times than in the past.
Pramipexole controls the symptoms of Parkinson's disease and restless legs syndrome but does not cure these conditions. Continue to take pramipexole even if you feel well. Do not stop taking pramipexole without talking to your doctor. If you are taking pramipexole to treat Parkinson's disease and you suddenly stop taking the medication, you may experience, fever, muscle stiffness, changes in consciousness, and other symptoms. If you are taking pramipexole to treat restless legs syndrome and you suddenly stop taking the medication, your symptoms may become worse than they were before you started taking this medication. Your doctor will probably decrease your dose gradually.
If you stop taking pramipexole for any reason, do not start to take the medication again without talking to your doctor. Your doctor will probably want to increase your dose again gradually.
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This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
Before taking pramipexole,
- tell your doctor and pharmacist if you are allergic to pramipexole or any other medications, or any of the ingredients in pramipexole tablets or extended- release tablets.Ask your doctor or pharmacist for a list of the inactive ingredients.
- tell your doctor and pharmacist what prescription and nonprescription medications vitamins, nutritional supplements and herbal products you are taking or plan to take. Be sure to mention any of the following: antihistamines; cimetidine (Tagamet); medications for allergies, mental illness, and nausea; metoclopramide (Reglan); sedatives; sleeping pills; and tranquilizers. . Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- tell your doctor if you have or have ever had mental illness, trouble controlling movement of your muscles,a sleep disorder other than restless legs syndrome, dizziness, fainting, low blood pressure, or kidney disease.
- tell your doctor if you are pregnant, plan to become pregnant or are breastfeeding. If you become pregnant while taking pramipexole, call your doctor.
- you should know that pramipexole may make you drowsy or may cause you to suddenly fall asleep during your regular daily activities. You might not feel drowsy before you suddenly fall asleep. Do not drive a car or operate machinery at the beginning of your treatment until you know how pramipexole will affect you. If you suddenly fall asleep while you are doing something such as watching television or riding in a car, or if you become very drowsy, call your doctor. Do not drive or operate machinery until you talk to your doctor.
- you should know that alcohol can add to the drowsiness caused by this medication. Tell your doctor if you regularly drink alcoholic beverages.
- you should know that pramipexole may cause dizziness, lightheadedness, nausea, fainting, or sweating when you get up too quickly from a sitting or lying position. This is more common when you first start taking pramipexole, or when your dose is increased. To avoid this problem, get out of the chair or bed slowly, resting your feet on the floor for a few minutes before standing up.
- you should know that some people who took medications such as pramipexole to treat Parkinson's disease or restless legs syndrome developed gambling problems, an increased interest in shopping or sex, overeating problems, or other intense urges or behaviors that were compulsive or unusual for them. There is not enough information to tell whether the people developed these problems because they took the medication or for other reasons. Call your doctor if you develop intense urges or have difficulty controlling any of these behaviors. Tell your family members about these risks so that they can call the doctor even if you do not realize that your behavior has become a problem.
- you should know that if you are taking the extended-release tablets, you may notice something that looks like a swollen tablet or swollen pieces of tablet in your stool. If this happens, especially along with a worsening of your Parkinson's disease symptoms, call your doctor.
What special dietary instructions should I follow?
Unless your doctor tells you otherwise, continue your normal diet.
If you are taking regular pramipexole tablets to treat Parkinson's disease, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
If you are taking regular pramipexole tablets to treat restless legs syndrome, skip the missed dose. Take your regular dose 2 to 3 hours before your next bedtime. Do not double the next dose to make up for the missed dose.
If you are taking the extended-release pramipexole tablets and you miss a dose, take the missed dose as soon as you remember it. However, if more than 12 hours passed since your missed dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Pramipexole may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
Causes Of Restless Legs
- nausea
- weakness
- dizziness
- loss of balance, falling
- difficulty falling asleep or staying asleep
- difficulty remembering
- abnormal dreams
- heartburn
- constipation
- diarrhea
- dry mouth
- swollen, stiff, or painful joints
- pain in back, arms or legs
- frequent urination or urgent need to urinate
- difficulty urinating or pain when urinating
Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately:
- hallucinations (seeing things or hearing voices that do not exist), confusion, aggressive behavior, agitation, abnormal thoughts
- changes in vision
- abnormal body movements and motions that you cannot control
- changes in the way you sit or stand that you cannot control, such as your neck bending forward, bending forward at the waist, or tilting sideways when you sit, stand or walk,
- dark, red or cola-colored urine
- muscle tenderness
- muscle stiffness or aching
- muscle weakness
Pramipexole may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
What should I know about storage and disposal of this medication?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Store the regular tablets away from light.
It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.
Symptoms of overdose may include the following:
- fast heart rate
Keep all appointments with your doctor.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
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What should I know about storage and disposal of this medication?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Store the regular tablets away from light.
It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.
Symptoms of overdose may include the following:
- fast heart rate
Keep all appointments with your doctor.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
You can't put together a list of biggest Casinos in the world and not include one from Sin City itself – in this case, it's the MGM Grand Las Vegas. Located on the Las Vegas Strip, it not only includes the huge 171,500 square-foot casino, but also the second largest hotel in the world by number of rooms, with an incredible 6,852. Simply known as Montreal Casino to locals, this venue is one of the largest gambling centres in the world, with a capacity of almost 4,000 people. Gamers in this casino can immerse themselves in over 3,200 slot machines, as well as 120 different gaming tables, across over three different floors. The Las Vegas Valley has the largest concentration of casinos in the United States. Based on revenue, Atlantic City, New Jersey ranks second, and the Chicago region third. Top American casino markets by revenue (2015 annual revenues): Las Vegas Strip $6.348 billion; Atlantic City $2.426 billion; Chicago region $2.002 billion; New York City $1. As a result of the completion of this expansion, the casino overtook Foxwoods Resort Casino to become the largest casino in the United States and one of the largest in the world based on gaming floor space. WinStar has 8,500 electronic games, a 55-table poker room, 100 total table games, Racer's off-track betting, high limit room, keno, and bingo.
Last Revised - 07/15/2018Victims of Mirapex (pramipexole dihydrochloride), an FDA approved drug which is used to treat Parkinson's Disease and restless leg syndrome, has been associated with compulsive behavior, including gambling addiction. Since its approval, scores of Mirapex users have claimed that they developed compulsive behaviors. This compulsive behavior is not limited to gambling addictions only, but people treated with Mirapex have suffered from other impulse control disorders such as sexual addictions, compulsive shopping and eating disorders. This compulsive behavior has led to the destruction of lives in the form of bankruptcies, suicide and broken marriages. The lawyers and attorneys at Jones Brown PLLC. are actively seeking victims of Mirapex and the destructive side effects associated with this drug.
What Is Mirapex?
Medication Restless Legs Syndrome
Mirapex (pramipexole dihydrochloride) is made by Boehringer Ingelheim and was approved by the FDA in 1997 for the treatment of Parkinson's disease symptoms and restless leg syndrome. Parkinson's patients are most often diagnosed after the age of 50. Symptoms of Parkinson's include tremors, stiff muscles and joints, poor posture, and a limited gate when walking. Parkinson's Disease occurs due to a lack of the neurotransmitter dopamine being delivered to certain critical areas of the brain. In patients with Parkinson's disease and restless leg syndrome, dopamine receptors may malfunction, causing involuntary muscle reflexes. Mirapex is a dopamine agonist and works by mimicking the effects of this chemical. Unfortunately, dopamine is also known to flood the brain of people who are anticipating a reward or excitement. Experts are of the opinion that such a biochemical reactions are behind the reports of compulsive behavior linked to Mirapex. The medication is licensed and distributed in North America by Pfizer USA, but it is patented and licensed by Boehringer Ingelheim Ltd., of Germany. Patients that were prescribed Mirapex allege they experience uncontrollable urges, often resulting in compulsive shopping, sexual addictions, eating disorders broken marriages, bankruptcy and host of psychological problems including depression and suicide.
Due to these reports from patients, the Mirapex package insert was changed to state adverse events include 'accidents (including fall), compulsive behaviors (sexual and pathological gambling), fatigue, hallucinations (all kinds), headache, hypotension, libido disorder, syncope, and blackouts.'
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Mirapex Lawsuits
Drugs That Cause Restless Legs
A study conducted in 2003 raised concern about the possible side effects of taking Mirapex. The study, done by the Muhammad Ali Parkinson Research Center at Barrow Neurological Institute in Arizona, found that 1.5 percent of the Parkinson's patients treated with Mirapex developed compulsive gambling behavior. This side effect occurred in patients taking Mirapex, but not with those taking other Parkinson medication. Another study presented at the International Congress of Parkinson's Disease and Movement Disorders in 2008, found that more than 13 percent of Parkinson's patients taking dopamine agonists suffered from at least one of the four severe behavioral addictions linked to Mirapex use: compulsive gambling, sexual addictions, compulsive shopping and eating disorders.
These side effects experienced by Mirapex users have resulted in bankruptcies, broken marriages, depression and even suicide. As a result of these impulse control problems, lawsuits against Pfizer and Boehringer Ingelheim are underway in an attempt to hold these companies accountable for marketing a dangerous drug and placing profits over the safety of their customers. If you or a loved one has developed a compulsive behavioral problem following Mirapex use, you may be eligible for compensation; however, there are strict deadlines plaintiffs must meet when filing dangerous drug lawsuits.
Do You Qualify For a Mirapex Lawsuit?
Manufacturers' Pfizer and Boehringer Ingelheim have failed to adequately warn consumers about the potential Mirapex side effects. Financial compensation may be available for patients who experienced uncontrollable urges, often resulting in compulsive shopping, sexual addictions, eating disorders broken marriages, bankruptcy and host of psychological problems including depression and suicide.
Our nationwide network experienced attorneys and medical staff here at Jones Brown Law are ready to help those who have been effected by those prescribed Mirapex. We strive to make working with us as simple, easy and uncomplicated as possible.
Requip Medication For Restless Leg Syndrome
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